ホーム 計算ツール
代理店ログイン

検索結果

Search Results for " E2 conjugating enzyme "

ターゲット

44

阻害剤

5

天然化合物

39

リコンビナントタンパク質

1

ライブラリー

カタログ番号 製品名 別名 ターゲット
T24136 Heclin E1/E2/E3 Enzyme
Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.
T5374 NAcM-OPT E1/E2/E3 Enzyme , NEDD8
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 (IC50: 79 nM).
T16102 ML-792 E1/E2/E3 Enzyme
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi...
T5199 COH000 E1/E2/E3 Enzyme
COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).
T16699 PYZD-4409 Others , E1/E2/E3 Enzyme
PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.
T16901 SMIP004 Apoptosis , Others , E1/E2/E3 Enzyme
SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.
T12261 NSC232003 E1/E2/E3 Enzyme
NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.
T7415 DKM 2-93 E1/E2/E3 Enzyme
DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).
T3517 RO8994 Mdm2 , E1/E2/E3 Enzyme , p53
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).
T2158 Nutlin-3 Nutlin3 E1/E2/E3 Enzyme
Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells.
T8428 Subasumstat TAK-981 E1/E2/E3 Enzyme
Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.
T7379 2-D08 E1/E2/E3 Enzyme , TAM Receptor
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
T6629 PYR-41 PYR41,PYR 41 Apoptosis , E1/E2/E3 Enzyme
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.
T16888 SJ-172550 Mdm2 , E1/E2/E3 Enzyme
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
T9236 WSB1 Degrader 1 Others , E1/E2/E3 Enzyme
WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.
T3653 MX69 Mdm2 , E1/E2/E3 Enzyme , IAP
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
T6149 YH239-EE Apoptosis , E1/E2/E3 Enzyme
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
T13244 Ubiquitination-IN-1 Others
T3317 SZL P1-41 Apoptosis , Others , E1/E2/E3 Enzyme
SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate...
T11980 MD-224 Mdm2 , E1/E2/E3 Enzyme , PROTACs
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
T7889 C25-140 Others , TNF , E1/E2/E3 Enzyme , NF-κB
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
T13349 WS-383 E1/E2/E3 Enzyme
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).
T10703 Mezigdomide CC-92480 Apoptosis , E1/E2/E3 Enzyme , Molecular Glues
Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide has antimyeloma activity.
T23371 SMER3 SMER 3 Others , Ligand for E3 Ligase
SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune respon...
T8564 BC-1382 Others , E1/E2/E3 Enzyme
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).
T4253 Skp2 Inhibitor C1 SKPin C1 Others , E1/E2/E3 Enzyme
Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.
T3110 PRT4165 NSC600157,PRT 4165 BMI-1 , Others , E1/E2/E3 Enzyme
PRT4165 (NSC600157) is a potent PRC1-mediated H2A ubiquitylation inhibitor.
T3549 Avadomide CC 122 Apoptosis , E1/E2/E3 Enzyme , Ligand for E3 Ligase
Avadomide (CC 122) is an orally available pleiotropic pathway modulator with potential antineoplastic activity.
T5555 Siremadlin NVP-HDM 201 E1/E2/E3 Enzyme
Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.
T6254 Idasanutlin RG7388,Ro 5503781 Mdm2 , E1/E2/E3 Enzyme
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
T6965 RG7112 RG-7112,RG 7112,RO5045337 Mdm2 , E1/E2/E3 Enzyme
RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
T16974 TAK-243 MLN7243 Apoptosis , E1/E2/E3 Enzyme , NF-κB
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exh...
T1493 BH3I-1 BHI1 BCL , E1/E2/E3 Enzyme
BH3I-1 (BHI1) is a Bcl-2 antagonist.
TQ0231 NVP-CGM097 CGM097 Mdm2 , E1/E2/E3 Enzyme
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
TQ0127 Navtemadlin AMG232,CS-1300 Mdm2 , E1/E2/E3 Enzyme
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
T6611 NSC697923 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran E1/E2/E3 Enzyme
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct me...
T2243 Serdemetan JNJ-26854165 Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
T6023 Nutlin-3a (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3 Apoptosis , E1/E2/E3 Enzyme , Autophagy
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.
T25465 GS143 GS-143,GS 143 IκB/IKK , E1/E2/E3 Enzyme , NF-κB
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and tran­scrip­tion of tar­get genes and does not inhibit protea...
T6585 SAR405838 MI773,MI 773,MI-77301,MI-773 Mdm2 , E1/E2/E3 Enzyme
MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
T8929 BC1618 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Mitophagy , Others , E1/E2/E3 Enzyme , AMPK
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling. It promotes mitochondrial fission, promotes autophagy and imp...
T6614 Nutlin-3b (+)-Nutlin-3 Mdm2 , E1/E2/E3 Enzyme
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
T9140 NAcM-OPT HCl(2089293-61-6 free base) NEDD8
NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
T13242 UbcH5c-IN-1 Others
UbcH5c-IN-1 is a selective small-molecule Ubiquitin-conjugating enzyme UbcH5c inhibitor (Kd: 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85).

Compounds

Heclin
T24136
Synonym:
Target: E1/E2/E3 Enzyme
NAcM-OPT
T5374
Synonym:
Target: E1/E2/E3 Enzyme, NEDD8
ML-792
T16102
Synonym:
Target: E1/E2/E3 Enzyme
COH000
T5199
Synonym:
Target: E1/E2/E3 Enzyme
PYZD-4409
T16699
Synonym:
Target: Others, E1/E2/E3 Enzyme
SMIP004
T16901
Synonym:
Target: Apoptosis, Others, E1/E2/E3 Enzyme
NSC232003
T12261
Synonym:
Target: E1/E2/E3 Enzyme
DKM 2-93
T7415
Synonym:
Target: E1/E2/E3 Enzyme
RO8994
T3517
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, p53
Nutlin-3
T2158
Synonym: Nutlin3
Target: E1/E2/E3 Enzyme
Subasumstat
T8428
Synonym: TAK-981
Target: E1/E2/E3 Enzyme
2-D08
T7379
Synonym:
Target: E1/E2/E3 Enzyme, TAM Receptor
PYR-41
T6629
Synonym: PYR41,PYR 41
Target: Apoptosis, E1/E2/E3 Enzyme
SJ-172550
T16888
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme
WSB1 Degrader 1
T9236
Synonym:
Target: Others, E1/E2/E3 Enzyme
MX69
T3653
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, IAP
YH239-EE
T6149
Synonym:
Target: Apoptosis, E1/E2/E3 Enzyme
Ubiquitination-IN-1
T13244
Synonym:
Target: Others
SZL P1-41
T3317
Synonym:
Target: Apoptosis, Others, E1/E2/E3 Enzyme
MD-224
T11980
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, PROTACs
C25-140
T7889
Synonym:
Target: Others, TNF, E1/E2/E3 Enzyme, NF-κB
WS-383
T13349
Synonym:
Target: E1/E2/E3 Enzyme
Mezigdomide
T10703
Synonym: CC-92480
Target: Apoptosis, E1/E2/E3 Enzyme, Molecular Glues
SMER3
T23371
Synonym: SMER 3
Target: Others, Ligand for E3 Ligase
BC-1382
T8564
Synonym:
Target: Others, E1/E2/E3 Enzyme
Skp2 Inhibitor C1
T4253
Synonym: SKPin C1
Target: Others, E1/E2/E3 Enzyme
PRT4165
T3110
Synonym: NSC600157,PRT 4165
Target: BMI-1, Others, E1/E2/E3 Enzyme
Avadomide
T3549
Synonym: CC 122
Target: Apoptosis, E1/E2/E3 Enzyme, Ligand for E3 Ligase
Siremadlin
T5555
Synonym: NVP-HDM 201
Target: E1/E2/E3 Enzyme
Idasanutlin
T6254
Synonym: RG7388,Ro 5503781
Target: Mdm2, E1/E2/E3 Enzyme
RG7112
T6965
Synonym: RG-7112,RG 7112,RO5045337
Target: Mdm2, E1/E2/E3 Enzyme
TAK-243
T16974
Synonym: MLN7243
Target: Apoptosis, E1/E2/E3 Enzyme, NF-κB
BH3I-1
T1493
Synonym: BHI1
Target: BCL, E1/E2/E3 Enzyme
NVP-CGM097
TQ0231
Synonym: CGM097
Target: Mdm2, E1/E2/E3 Enzyme
Navtemadlin
TQ0127
Synonym: AMG232,CS-1300
Target: Mdm2, E1/E2/E3 Enzyme
NSC697923
T6611
Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran
Target: E1/E2/E3 Enzyme
Serdemetan
T2243
Synonym: JNJ-26854165
Target: Apoptosis, Mdm2, E1/E2/E3 Enzyme, p53
Nutlin-3a
T6023
Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3
Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy
GS143
T25465
Synonym: GS-143,GS 143
Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB
SAR405838
T6585
Synonym: MI773,MI 773,MI-77301,MI-773
Target: Mdm2, E1/E2/E3 Enzyme
BC1618
T8929
Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK
Nutlin-3b
T6614
Synonym: (+)-Nutlin-3
Target: Mdm2, E1/E2/E3 Enzyme
NAcM-OPT HCl(2089293-61-6 free base)
T9140
Synonym:
Target: NEDD8
UbcH5c-IN-1
T13242
Synonym:
Target: Others
カタログ番号 製品名 別名 ターゲット
T4S0181 Hinokiflavone MMP , BCL , E1/E2/E3 Enzyme
Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO...
T9352 Hydrocotarnine Others
hydrocotarnine is an inhibitor of Cbl.
T4036 Solasodine Solancarpidine,Purapuridine,Solasodin Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma...
T2947 Indole-3-carbinol I3C,3-Indolemethanol,Indole-3-Methanol E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T6S2123 Ginkgolic Acid Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),Ginkgolic acid C15:1 Others , E1/E2/E3 Enzyme
Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPJ-01039 UBE2K Protein, Human, Recombinant (His & SUMO) Human E. coli
Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum...
TMPJ-01138 UBE2S Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activat...
TMPJ-01038 UBE2K Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain, with highest levels found in cortex and striatum, and at lower levels in cerebellum...
TMPJ-00571 UBE2D3 Protein, Human, Recombinant Human E. coli
UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubi...
TMPJ-01198 UBE2R2 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 R2 (UBE2R2) is a modification enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2R2 is involved in cell growth and transformation. It accepts ubiquitin from the E1 complex...
TMPJ-01047 UBE2H Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 H (UBE2H) belongs to the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived protei...
TMPJ-01221 UBE2J2 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 J2 (UBE2J2) belongs to the ubiquitin-conjugating enzyme family. UBE2J2 is involved in the ubiquitiantion. UBE2J2 located in the membrane of the endoplasmic reticulum, catalyzes the covalen...
TMPJ-01334 UBE2Z Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta, pancreas, spleen, and testis. ...
TMPY-00611 UBE2B Protein, Mouse, Recombinant Mouse E. coli
The ubiquitin-conjugating enzyme E2B (Ube2b) is a critical target gene of androgen receptor (AR), mediating the function of AR in spermatogenesis by promoting H2A ubiquitylation. Moreover, UBE2B plays an important role i...
TMPJ-00999 UBE2D1 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes...
TMPJ-00033 UBE2B Protein, Human, Recombinant (His) Human Human Cells
Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2...
TMPY-02426 UBE2D1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1), a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, which is short for stimulator of iron (Fe) transport. In other words, UbcH5A is significantly up...
TMPJ-01035 UBE2G2 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 10...
TMPY-02607 Ube2H Protein, Human, Recombinant Human E. coli
UBE2H is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPJ-01053 UBE2I Protein, Human, Recombinant (GST) Human E. coli
SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However, instead of conjugating ubiquitin, UBC9 conjugates a ubiquitin ho...
TMPJ-01403 UBE2D4 Protein, Human, Recombinant (GST) Human E. coli
Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational...
TMPJ-00985 UBE2A Protein, Human, Recombinant (GST, His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 (UBE2A) is a member of the E2 Ubiquitin-Conjugating Enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived prot...
TMPJ-01100 UBE2V1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inact...
TMPJ-01131 UBE2V2 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N....
TMPH-03074 UBC5A Protein, Japonica rice, Recombinant (His & Myc) Rice E. coli
E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins.
TMPH-03526 Cap8A Protein, S. aureus, Recombinant (His) Staphylococcus aureus in vitro E. coli expression system
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate comp...
TMPY-02642 UBE2W Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important c...
TMPY-02842 UBE2L6 Protein, Human, Recombinant (His) Human E. coli
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain....
TMPY-02496 Rad6/UBE2A Protein, Human, Recombinant (His) Human E. coli
Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication ...
TMPJ-01327 ATG10 Protein, Human, Recombinant (His, T7) Human E. coli
Ubiquitin-Like-Conjugating Enzyme ATG10 (ATG10) is a ubiquitous 28kDa member of the ATG10 family protein. ATG10 acts as an E2-like enzyme, catalyzes the transfer of ATG12 to ATG5 during in the initial stages of autophage...
TMPY-04263 UBE2T Protein, Human, Recombinant (His) Human E. coli
Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several cancers, representing an attractive target for the development of inhibitors. Notably, UBE2T locate...
TMPJ-01354 ATG3 Protein, Human, Recombinant Human E. coli
Ubiquitin-like-conjugating enzyme ATG3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. ATG3 exhibits 98% aa sequence identity with both its ...
TMPH-01657 MAGEA3 Protein, Human, Recombinant (His & Myc) Human E. coli
Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubi...
TMPY-02604 UBE2D4 Protein, Human, Recombinant (His) Human E. coli
UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed...
TMPH-01781 NSMCE3 Protein, Human, Recombinant (His) Human E. coli
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohe...
TMPH-01261 NEDD4L Protein, Human, Recombinant (GST) Human E. coli
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by trig...
TMPY-02605 UBE2F Protein, Human, Recombinant (His) Human E. coli
UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPY-02608 UBC9/UBE2I Protein, Human, Recombinant Human E. coli
UBE2I is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPY-02609 UBE2M Protein, Human, Recombinant Human E. coli
UBE2M is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed ...
TMPY-02606 UBE2G1 Protein, Human, Recombinant Human E. coli
UBE2G1 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed...
TMPH-01269 SMURF2 Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMA...
TMPY-02950 WWP2 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thio...
TMPY-01654 ITCH Protein, Human, Recombinant (aa 526-903) Human E. coli
E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ub...
TMPH-01268 SIAH1 Protein, Human, Recombinant (GST) Human E. coli
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester...
UBE2K Protein, Human, Recombinant (His & SUMO)
TMPJ-01039
Species: Human
Expression System: E. coli
UBE2S Protein, Human, Recombinant (GST)
TMPJ-01138
Species: Human
Expression System: E. coli
UBE2K Protein, Human, Recombinant (GST)
TMPJ-01038
Species: Human
Expression System: E. coli
UBE2D3 Protein, Human, Recombinant
TMPJ-00571
Species: Human
Expression System: E. coli
UBE2R2 Protein, Human, Recombinant (His)
TMPJ-01198
Species: Human
Expression System: E. coli
UBE2H Protein, Human, Recombinant (GST)
TMPJ-01047
Species: Human
Expression System: E. coli
UBE2J2 Protein, Human, Recombinant (GST)
TMPJ-01221
Species: Human
Expression System: E. coli
UBE2Z Protein, Human, Recombinant (His)
TMPJ-01334
Species: Human
Expression System: E. coli
UBE2B Protein, Mouse, Recombinant
TMPY-00611
Species: Mouse
Expression System: E. coli
UBE2D1 Protein, Human, Recombinant (GST)
TMPJ-00999
Species: Human
Expression System: E. coli
UBE2B Protein, Human, Recombinant (His)
TMPJ-00033
Species: Human
Expression System: Human Cells
UBE2D1 Protein, Human, Recombinant (His)
TMPY-02426
Species: Human
Expression System: E. coli
UBE2G2 Protein, Human, Recombinant (GST)
TMPJ-01035
Species: Human
Expression System: E. coli
Ube2H Protein, Human, Recombinant
TMPY-02607
Species: Human
Expression System: E. coli
UBE2I Protein, Human, Recombinant (GST)
TMPJ-01053
Species: Human
Expression System: E. coli
UBE2D4 Protein, Human, Recombinant (GST)
TMPJ-01403
Species: Human
Expression System: E. coli
UBE2A Protein, Human, Recombinant (GST, His)
TMPJ-00985
Species: Human
Expression System: E. coli
UBE2V1 Protein, Human, Recombinant (His)
TMPJ-01100
Species: Human
Expression System: E. coli
UBE2V2 Protein, Human, Recombinant (His)
TMPJ-01131
Species: Human
Expression System: E. coli
UBC5A Protein, Japonica rice, Recombinant (His & Myc)
TMPH-03074
Species: Rice
Expression System: E. coli
Cap8A Protein, S. aureus, Recombinant (His)
TMPH-03526
Species: Staphylococcus aureus
Expression System: in vitro E. coli expression system
UBE2W Protein, Human, Recombinant (His)
TMPY-02642
Species: Human
Expression System: E. coli
UBE2L6 Protein, Human, Recombinant (His)
TMPY-02842
Species: Human
Expression System: E. coli
Rad6/UBE2A Protein, Human, Recombinant (His)
TMPY-02496
Species: Human
Expression System: E. coli
ATG10 Protein, Human, Recombinant (His, T7)
TMPJ-01327
Species: Human
Expression System: E. coli
UBE2T Protein, Human, Recombinant (His)
TMPY-04263
Species: Human
Expression System: E. coli
ATG3 Protein, Human, Recombinant
TMPJ-01354
Species: Human
Expression System: E. coli
MAGEA3 Protein, Human, Recombinant (His & Myc)
TMPH-01657
Species: Human
Expression System: E. coli
UBE2D4 Protein, Human, Recombinant (His)
TMPY-02604
Species: Human
Expression System: E. coli
NSMCE3 Protein, Human, Recombinant (His)
TMPH-01781
Species: Human
Expression System: E. coli
NEDD4L Protein, Human, Recombinant (GST)
TMPH-01261
Species: Human
Expression System: E. coli
UBE2F Protein, Human, Recombinant (His)
TMPY-02605
Species: Human
Expression System: E. coli
UBC9/UBE2I Protein, Human, Recombinant
TMPY-02608
Species: Human
Expression System: E. coli
UBE2M Protein, Human, Recombinant
TMPY-02609
Species: Human
Expression System: E. coli
UBE2G1 Protein, Human, Recombinant
TMPY-02606
Species: Human
Expression System: E. coli
SMURF2 Protein, Human, Recombinant (His)
TMPH-01269
Species: Human
Expression System: E. coli
WWP2 Protein, Human, Recombinant (His & GST)
TMPY-02950
Species: Human
Expression System: Baculovirus-Insect Cells
ITCH Protein, Human, Recombinant (aa 526-903)
TMPY-01654
Species: Human
Expression System: E. coli
SIAH1 Protein, Human, Recombinant (GST)
TMPH-01268
Species: Human
Expression System: E. coli
カタログ番号 製品名
L8600 Ubiquitination Compound Library

210 compounds
A unique collection of 210 ubiquitination related small chemicals can be used for high throughput and high content screening;